Instituto de Investigaciones Médicas (IDIM) - CONICET / UBA


* Autoridades *

Director:

Dr. Carlos J. Pirola, F.A.H.A.

Subdirector:

Dra. Silvia Sookoian, F.A.A.S.L.D.

Consejo Directivo:

Dr. Carlos J. Pirola, Dra. Silvia Sookoian, Dra. Silvia Ines Garcia, Dra. Adriana Losavio, Dra. Paula Heller, Dr. Claudio Pereira, Dr. Guillermo Bertran, Dra. Mariana Miranda, Dra. Estela Cardoso, Lic. Melisa Msartinez Saye

Secretaria IDIM:

Jesica M. Matera (SINAPA - CONICET), Lic. Miguel A. Pini (SINAPA - CONICET), Ezequiel Caracotche Armesto (SINAPA - CONICET).


* Departamentos de Investigación *

Dpto. de Biologia Molecular y Apoptosis

  • Jefe: Dra. Mónica A. Costas - Investigadora Principal CONICET
  • Equipo:
    • Dra. Fernanda Rubio - Investigadora Adjunta CONICET
    • Dra. Laura Panelo - Becaria Posdoctoral CONICET
    • Lic. Mileni Sohares Machado - Becaria Doctoral (c/Paises Latinoamericanos) CONICET
    • Lic. Maria Cecilia Lira - Pasante CONICET
    • Lic. Francisco Damian Rosa - Pasante CONICET

Dpto. de Canales Iónicos

  • Equipo:
    • Dr. Luciano Galizia - Investigador Asistente CONICET
    • Dra. Gabriela Marino - Investigadora Asistente CONICET
    • Lic. Alejandra Palma - Becaria Fin de Doctorado CONICET

Dpto. de Cardiología Molecular

  • Jefa: Dra. Silvia I. Garcia - Investigadora Independiente CONICET
  • Equipo:
    • Dra. Silvina Landa - Investigadora Asistente CONICET
    • Dr. Mariano Schuman - Investigador Asistente CONICET
    • Dra. Ludmila Peres Diaz - Becaria Posdoctoral CONICET
    • Lic. Maia Aisicovich - Becaria Doctoral CONICET

Dpto. de Comportamiento de Cánidos

  • Jefa: Dra. Mariana Bentosela - Investigadora Independiente CONICET
  • Equipo:
    • Lic. Camila Cavalli - Becaria Doctoral CONICET
    • Lic. Marina Victoria Dzik - Pasante CONICET

Dpto. de Endocrinología Experimental

  • Jefa: Dra. Liliana Contreras - Investigadora Independiente CONICET
  • Equipo:
    • Dra. Estela Cardoso - Personal de Apoyo Profesional Principal CONICET
    • Alejandro Arregger - Personal Asistencial  UBA - Investigador Clínico CONICET
    • Rocio Sanchez - Becaria UBA

Dpto. de Genetica y Biología Molecular de Enfermedades Complejas

  • Jefe: Dr. Carlos J. Pirola - Investigador Superior CONICET
  • Equipo:
    • Dra. Silvina Landa - Investigadora Asistente CONICET
    • Dra. Mariana Tellechea - Investigadora Asistente CONICET
    • Lic. Adrian Salatino - Becario Doctoral CONICET
    • Lic. Melisa Mensegue - Pasante CONICET

Dpto. de Hematología Investigación

  • Jefes: Dra. Paula Heller - Investigadora Independiente CONICET
    • Dra. Rosana Marta - Investigadora Independiente CONICET
  • Equipo:
    • Dra. Paola Lev - Investigadora Adjunta CONICET
    • Dra. Nora Goette - Bioquímica - Doctora UBA
    • Dra. Ana Glembotsky - Investigadora Adjunta CONICET
    • Dr. Matias Grodzielzki - Becario Posdoctoral CONICET
    • Lic. Cecilia Marin Oyarzun - Becaria Doctoral CONICET
    • Lic. Maria Constanza Baroni Prieto - Becaria Doctoral Agencia Nacional de Promoción Cientifica y Técnica

Dpto. de Hepatogía Clínica y Molecular

  • Jefa: Dra. Silvia Sookoian - Investigadora Principal CONICET
  • Equipo:
    • Lic. Adrian Salatino - Becario Doctoral CONICET
    • (Personal de Apoyo Profesional CONICET en proceso de designación)

Dpto. de Nefrología Experimental

  • Jefe: Dra. Elisabet Mónica Oddo - Bioquímica UBA
  • Equipo:
    • Pablo Azurmendi - Bioquímico Doctor de la UBA
    • Carolina Muchnik - Bioquímica UBA
    • Rodolfo S. Martin - Médico Investigador, doctor de la UBA
    • Fernando Ibarra - Médico Investigador, JTP, doctor de la UBA
    • Susana Cesario - Técnica UBA
    • Adriana Scerbo - Técnica UBA
    • Jorge Toledo - Técnico UBA
    • Sandra Gabriela Vlachovsky - Pasante CONICET

Dpto. de Neurofisiología Experimental

  • Jefa: Dra. Adriana Losavio - Investigadora Independiente CONICET
  • Equipo:
    • Dr. Salomón Muchinik - UBA
    • Dr. Guillermo Bertran - Investigador Adjunto CONICET
    • Técnica Fernanda Rodriguez - UBA
    • Maximiliano Rodolfo Hurtado Paso - Pasante CONICET

Dpto. de Parasitología Molecular

  • Jefe: Dr. Claudio A. Pereira - Investigador Principal CONICET
  • Equipo:
    • Dra. Mariana Miranda - Investigadora Adjunta CONICET
    • Lic. Fabio Di Girolamo - Personal de Apoyo Profesional Adjunto CONICET
    • Lic. Melisa Martinez Saye - Becaria Posdoctoral CONICET
    • Lic. Chantal Reigada - Becaria Doctoral CONICET
    • Lic. Edward Valera - Becario Doctoral (c/Paises Latinoamericanos) CONICET

Dpto. de Psicología Experimental y Aplicada

  • Jefa: Dra. Giselle Kamenetzky - Investigadora Asistente CONICET
  • Equipo:
    • Dr. Lucas Cuenya - Investigador Asistente CONICET
    • Lic. Andrea Suarez - Becaria Fin de Doctorado CONICET
    • Lic. Veronika Diaz Abraham - Becaria Doctoral CONICET
    • Lic. Mariana Psyrdellis - Becaria Doctoral CONICET

Bioterio

  • Jefe: (en proceso de designación)
  • Sub-Jefa: Dra. Silvia I. Garcia - Investigadora Asistente CONICET
  • Equipo:
    • Noelia Gonzales Mansilla - Personal de Apoyo Técnica Asociada CONICET
    • Paula Roviaro - Personal de Apoyo Técnica Asistente CONICET

* Investigación - Trabajos publicados entre los años 2011 y 2016 *

Departamento Biología Molecular y Apoptosis

Rol de coactivadores de receptores nucleares en la proliferación celular, apoptosis y desarrollo de tumores.

Participación de RAC3 en la adquisición del fenotipo de célula madre tumoral y contribución de señales inflamatorias para su rol oncogénico.

TITULO AUTORES REVISTA EDITORIAL
EFECTOS DE LA RAPAMICINA EN LOS PROCESOS DE SENESCENCIA Y AUTOFAGIA EN LÍNEAS CELULARES HUMANAS P. N. Fernández Larrosa - M. Ruiz Grecco - C. Alvarado - S. Micenmacher - C. Aguirre - G. Martinez Noel - M. Costas - M.F. Rubio MEDICINA (BUENOS AIRES) MEDICINA (BUENOS AIRES)
La sobreexpresión de RAC3 es una señal transformante y proliferativa que contribuye al desarrollo tumoral Alvarado CV - S M MICENMACHER - M A RUIZ GRECCO - Rubio MF - P N FERNÁNDEZ LARROSA - Costas MA MEDICINA (BUENOS AIRES) MEDICINA (BUENOS AIRES)
Cyclin D1 is a NF-kB corepressor P. N. Fernández Larrosa - M.F. Rubio - C. Alvarado - L. Panelo - M. Ruiz Grecco - G. Colo - G. Martinez Noel - S. Micenmacher - M. Costas BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH ELSEVIER SCIENCE BV
The nuclear receptor coactivator RAC3 inhibits autophagy Fernandez Larrosa P - Alvarado C - Rubio M. Fernanda - Ruiz Grecco M - Micenmacher S  - Martinez Noel G - Panelo L.C. - Costas M A CANCER SCIENCE WILEY-BLACKWELL PUBLISHING, INC
The levels of RAC3 expression are up regulated by TNF in the inflammatory response C V ALVARADO - M F RUBIO - P N FERNÁNDEZ LARROSA - L. C. PANELO - P. J. ARZUMENDI - M A RUIZ GRECCO - GISELLE ASTRID MARTÍNEZ NOEL - M A COSTAS FEBS Open Bio ELSEVIER SCIENCE BV
RAC3 more than a nuclear receptor coactivator: A key inhibitor of senescence that is down-regulated in aging Fernandez Larrosa P N - Ruiz Grecco M - Mengual Gomez D - Alvarado C V - Panelo L.C. - Rubio M F - Alonso D F - Gómez D E - Costas M A Cell Death and Disease Nature Publishing Group
Integrative study at the biochemical level in a intertidal crab from Mar Chiquita coastal lagoon (Buenos Aires, Argentina) upon acute exposure to high zinc Panelo L. - Panzeri,A. - del Valle, J.C - López Mañanes, A,A. Pan-American Journal of Aquatic Sciences Pablo Muniz

 

Departamento Canales Iónicos

Transporte iónico en células BeWo, derivadas de trofoblasto de placenta humana. Regulación de CRTFy MDR-1 en células K562 con multidroga resistencia y células HEK. Regulacién del canal de sodio epitelias ENaC por proteínas Shroom. Expresión en ovocitos de Xenopus Iaevis.

TITULO AUTORES REVISTA EDITORIAL
Functional interaction between AQP2 and TRPV4 in renal cells Galizia L - Pizzoni A - Fernandez J - Rivarola V - Capurro C - Ford P JOURNAL OF CELLULAR BIOCHEMISTRY JOHN WILEY & SONS INC
El litio y su relación con la Acuaporina-2 y el canal de sodio ENaC Galizia L - Marino G - Kotsias B MEDICINA Sigma
Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta Marino GI, - Kotsias BA PLACENTA W B SAUNDERS CO LTD
Hypotonic regulation of mouse epithelial sodium channel in Xenopus laevis oocytes Luciano Galizia - Gabriela I. Marino - Alejandro Ojea - Basilio A. Kotsias JOURNAL OF MEMBRANE BIOLOGY SPRINGER
The Migratory Capacity of Human Trophoblastic BeWo Cells: Effects of Aldosterone and the Epithelial Sodium Channel Marino GI. - Assef YA. - Kotsias BA JOURNAL OF MEMBRANE BIOLOGY SPRINGER
Las publicaciones científicas argentinas Kotsias BA Medicina (Buenos Aires) Medicina (Buenos Aires)
Cystic fibrosis transmembrane regulator (CFTR) in human trophoblast BeWo cells and its relation to cell migration Marino GI - Kotsias BA PLACENTA W B SAUNDERS CO LTD
Funciones de los canales iónicos CFTR Y ENAC en la fibrosis quística Palma AG - Kotsias BA - Marino GI MEDICINA (BUENOS AIRES) MEDICINA (BUENOS AIRES)
CFTR channel in oocytes from Xenopus laevis and its regulation by xShroom1 protein. Palma A - Galizia L - Kotsias BA - Marino G PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY SPRINGER

 

Departamento Cardiología Molecular

Estudio del sistema de la Hormona Liberadora de Tirotrofina en el corazón de roedores.

Estudio del sistema de la TRH cardiaco en el desarrollo de la hipertrofia, remodelación y regeneración cardíaca.

TITULO AUTORES REVISTA EDITORIAL
Angiotensin-(1-7) Through Mas Receptor Upregulates Neuronal Norepinephrine Transporter Via Akt And Erk1/2-Dependent Pathways María A. Lopez Verrilli - Martín Rodriguez Fermepín - Nadia Longo Carbajosa - Silvina Landa - Bruno D. Cerrato - Silvia García - Belisario E. Fernandez - Mariela M. Gironacci JOURNAL OF NEUROCHEMISTRY WILEY-BLACKWELL PUBLISHING, INC
Cardiac thyrotropin-releasing hormone mediates left ventricular hypertrophy in spontaneously hypertensive rats Schuman ML - Landa MS - Tobli JE - Peres Diaz LS - ALVAREZ AL - Finkielman S - Paz L - Cao G - Pirola CJ - Garcia SI HYPERTENSION LIPPINCOTT WILLIAMS & WILKINS
HYROTROPIN-RELEASING HORMONE (TRH) MAY MEDIATE SYMPATHETIC ACTION AND ARTERIAL BLOOD PRESSURE INCREASE IN OFFSPRING OF MATERNAL OBESITY LANDA, MARIA SILVINA - SCHUMAN, MARIANO LUIS - Peres Diaz Ludmila - GARCIA , SILVIA INES - PIROLA, CARLOS JOSE HYPERTENSION LIPPINCOTT WILLIAMS & WILKINS
Thyrotropin-Releasing Hormone Overexpression induces structural changes of the Left Ventricle in the normal Rat heart Mariano L. Schuman - Ludmila S Peres Diaz - María S. Landa - Jorge E Toblli - Gabriel Cao - Azucena Alvarez - Samuel Finkielman - Carlos J. Pirola - Silvia I. García AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY AMER PHYSIOLOGICAL SOC
Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis Zhou X - Chen K - Wang Y - Schuman M - Lei H - Sun Z JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY AMER SOC NEPHROLOGY

 

Departamento Comportamiento de Cánidos

Estudio del efecto del aprendizaje en las capacidades comunicativas que los perros despliegan en la interacción con las personas.

TITULO AUTORES REVISTA EDITORIAL
Communication between domestic dogs and humans: effects of shelter housing upon the gaze to the human Gabriela Barrera - Alba Mustaca - Mariana Bentosela ANIMAL COGNITION SPRINGER HEIDELBERG
Gaze at the human face in shelter and pet dogs. Gabriela Barrera - Alba Mustaca - Mariana Bentosela ANIMAL COGNITION SPRINGER HEIDELBERG
Comunicación visual entre perros y humanos: Influencia de la sociabilidad Jakovcevic - Elgier - Barrera - Mustaca - Bentosela Revista Argentina de Ciencias del Comportamiento Universidad Nacional de Córdoba
Cognición social en animales y humanos: ¿Es posible establecer un continuo? Jakovcevic Adriana - Irrazábal Marcos - Bentosela Mariana SUMA PSICOLOGICA Fundación Universitaria Konrad Lorenz
Pointing following in dogs: are simple or complex cognitive mechanisms involved? Elgier, A - Jakovcevic, A - Mustaca, A - Bentosela, M ANIMAL COGNITION SPRINGER HEIDELBERG
Do more sociable dogs gaze longer to the human face than less sociable ones? Jakovcevic, A - Mustaca, A - Bentosela, M BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV
Learning Interspecific Communicative Responses in Pampas Foxes (Lycalopex gymnocercus) Barrera Gabriela - Jakovcevic Adriana - Mustaca Alba - Bentosela Mariana BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV
MIRA LO QUE TE MUESTRO: COMUNICACIÓN REFERENCIAL ENTRE PERROS DOMÉSTICOS (CANIS FAMILIARIS) Y HUMANOS Jakovcevic, A - Bentosela, M Interdisciplinaria Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines (CIIPCA)
RELACIÓN ENTRE EL TIPO DE ALOJAMIENTO Y LAS RESPUESTAS DE MIRADA, SOCIABILIDAD Y MIEDO-APACIGUAMIENTO EN PERROS Barrera, G - Giamal, Y - Mustaca, A - Bentosela, M SUMA PSICOLOGICA Fundación Universitaria Konrad Lorenz
Dogs' Eavesdropping from People's Reactions in Third Party Interactions Freidin, E. - Putrino, N. - D´Orazio, M. - Bentosela, M. PLOS ONE PUBLIC LIBRARY SCIENCE
FRUSTRATION BEHAVIORS IN DOMESTIC DOGS Jakovcevic, A. - Elgier, A - Mustaca, A - Bentosela, M JOURNAL OF APPLIED ANIMAL WELFARE SCIENCE ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
Evaluación del temperamento en perros de refugio y de familia. Un estudio comparativo Barrera, G. - Giamal, Y. - Fagnani, J. - Mustaca, A. - Bentosela, M. Revista Colombiana de Psicología Universidad Nacional de Colombia
Dog's discrimination of Human Selfish and Generous Attitudes: The role of individual recognition, experience, and experimenters gender Carballo F. - Freidin E. - Putrino N. - Shimabukuro C. - Casanave E. - Bentosela M. PLOS ONE PUBLIC LIBRARY SCIENCE
Effects of learning on social and non-social behaviors during a problem solving task in shelter and pet dogs Barrera, G. - Fagnani, J. P. - Carballo, F. - Giamal, Y. -  Bentosela, M. JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH ELSEVIER SCIENCE INC
Direct reciprocity in animals: The roles of bonding and affective processes Freidin, E. - Carballo, F. - Bentosela, M. International journal of Psychology Wyley online library
Estudios Sobre Cooperación en Perros Domésticos: Una Revisión Crítica Carballo, F - Freidin, E. - Bentosela, M Revista Colombiana de Psicología Universidad Nacional de Colombia
Following human pointing: Where do dogs (Canis familiaris) look at to find food? Carballo, F. - Freidin, E. - Casanave, E. - Bentosela, M. BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV
Post-Conflict Affiliative Behaviors Towards Humans in Domestic Dogs (Canis familiaris). Camila María Cavalli - Marina Victoria Dzik - Fabricio Carballo - Mariana Bentosela International Journal of Comparative Psychology eScholarship University of California
Sociability and Gazing Toward Humans in Dogs and Wolves: Simple Behaviors with Broad Implications. Bentosela, M. - Wynne, C - D´Orazio, M - Élgier, A. - Udell, M Journal of the Experimental Analysis of Behavior Amy Odum, Utah State University
Tolerance to delayed reward tasks in social and non-social contexts. Fagnani, J - Barrera, G - Carballo, F - Bentosela, M BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV

 

Departamento Endocrinologia Experimental

Impacto de la enfermedad renal en la regulación de la secreción de cortisol. Prevalencia de enfermedad adrenocortical en pacientes hipotensos con insuficiencia renal crónica en hemodiálisis. Diagnóstico y seguimiento mediante técnicas poco invasivas.Valor de los esteroides en saliva para la detección precoz de hipercorticismo endógeno en estadío subclínico.

Impacto de la enfermedad renal sobre la función adrenal y testicular en pacientes asistidos en un hospital universitario. Aplicación de un algoritmo inicial no invasivo.

Hiperactividad hipotálamo-hipófiso-adrenal y función mnésica en el envejecimiento. Estudio no invasivo.

TITULO AUTORES REVISTA EDITORIAL
Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease Cardoso EML - Contreras LN - Tumilasci EG - Elbert A - Aguirre EC - Aquilano DR - Arregger AL NEPHROLOGY DIALYSIS TRANSPLANTATION OXFORD UNIV PRESS
An accurate non-invasive approach to diagnose Cushing's syndrome in at-risk populations Estela ML Cardoso - Alejandro L Arregger - Gloria Monardes - Liliana N Contreras STEROIDS ELSEVIER SCIENCE INC
Adrenocortical function in hypotensive patients with end stage renal disease Alejandro l. Arregger - Estela ML Cardoso - Alfredo Zucchini - Elvira C. Aguirre - Alicia Elbert - Liliana N. Contreras STEROIDS ELSEVIER SCIENCE INC
Hormonal secretion and quality of life in Nelson´s syndrome and Cushing´s Disease after long-acting repeatable Octreotide. A short series and update Arregger AL - Cardoso EML - Sandoval OB - Tumilasci EGM - Sanchez R - Contreras LN  AMERICAN JOURNAL OF THERAPEUTICS LIPPINCOTT WILLIAMS & WILKINS
Benzidine Staining Method to Detect Neutrophils in Whole Saliva of Patients with Renal Disease Cardoso EML - Arregger AL - Budd D - Elverdín JC - Tumilasci G - Contreras LN International Journal of Clinical & Medical Imaging:open access Omics Publishing Group
Scrrening for primary aldosteronism in an argentinian population:a multicenter prospective study Leal Reyna M - Gómez RM - Lupi SN - Belli SH - Fenili CA - Martinez MS - Ruibal GF - Rossi MA - Chervin RA - Cornaló D - Contreras LN - Costa L - Nofal MT - Damilano SA - Pardes EM Archives of Endocrinology and Metabolism SP SegmentoFarma Editores
The benzidine staining-method to detect neutrophils in whole saliva of patients with renal disease Cardoso EML - Arregger AL - Budd D - Elverdín JC - Tumilasci G - Contreras LN International Journal of Clinical & Medical Imaging:open access Omics Publishing Group
Dynamics of salivary cortisol in chronic kidney disease patients at stages 1 through 4. Cardoso EM - Arregger AL - Budd D - Zucchini AE - Contreras LN.
CLINICAL ENDOCRINOLOGY WILEY-BLACKWELL PUBLISHING, INC

 

Departamento Genética y Biología Molecular de Enfermedades Complejas

Regulación de la presión arterial y hormonas que afectan el apetito, la saciedad, el gasto energético y la adiposidad en modelos experimentales caracterizados por la sobrexpresión de tiroliberina (TRH). Biologia de Sistemas del Sindrome Metabolico.

Genetica y epigenetica del Sindrome metabolico con enfasis en la hipertension arterial, obesidad, diabetes tipo 2 e higado graso aplicando diversas tecnicas de Biologia Molecular, incluyendo secuenciación de próxima generacion. Ultimamente hemos desarrollado experiencia en estas enfermedades complejas no trasmisibles desde la metabolomica, unificando conocimiento mediante Biologia de sistemas. Hemos integrado modelos animales con estudios de poblaciones de pacientes desde hace varios años siendo pioneros en lo que antes era investigacion clinica y hoy se ha dado en llamar Medicina Traslacional o Personalizada.

TITULO AUTORES REVISTA EDITORIAL
Cardiac thyrotropin-releasing hormone mediates left ventricular hypertrophy in spontaneously hypertensive rats Schuman ML - Landa MS - Tobli JE - Peres Diaz LS - ALVAREZ AL - Finkielman S - Paz L - Cao G - Pirola CJ - Garcia SI HYPERTENSION LIPPINCOTT WILLIAMS & WILKINS
Cyclooxygenase inhibition Up-regulates liver carnitine palmitoyltransferase 1A expression and improves fatty liver Rosselli MS - Burgueño AL - Pirola CJ - Sookoian S HEPATOLOGY JOHN WILEY & SONS INC
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on susceptibility and histological severity of nonalcoholic fatty liver disease Silvia Sookoian - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Methodological Concerns About a Recent Meta-Analysis of the Influence of the I148M Variant ofPatatin-Like Phospholipase Domain Containing 3 on the Susceptibility and Histological Severity of Nonalcoholic Fatty Liver Disease Silvia Sookoian - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Targeting the renin-angiotensin system: Potential beneficial effects of the angiotensin II receptor bloxkers in patients with nonalcholic steatohepatitis Silvia Sookoian - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease Sookoian S - Fernandez Gianotti T - Rosselli MS - Burgueño AL - Castaño GO - Pirola CJ ATHEROSCLEROSIS ELSEVIER IRELAND LTD
Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4 Sookoian S - Burgueño AL - Fernandez Gianotti T - Marillet G - Pirola CJ BIOLOGICAL PSYCHOLOGY ELSEVIER SCIENCE BV
Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 (STAT3) Gianotti TF - Castaño G - Gemma C - Burgueño A - Rosselli MS - Pirola CJ - Sookoian S METABOLISM-CLINICAL AND EXPERIMENTAL W B SAUNDERS CO-ELSEVIER INC
Metabolic Syndrome: From the Genetics to the Pathophysiology Silvia Sookoian - Carlos J. Pirola CURRENT HYPERTENSION REPORTS CURRENT MEDICINE GROUP
Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research Sookoian S - Fernadez Giannotti T - Burgueño A - Pirola CJ Biomolecular Concepts Walter de Gruyter GmbH & Co. KG
Functional characterization of TLR4 +3725 G/C polymorphism and association with protection against overweight Alberto Penas Steinhardt - Lucia S Barcos - Fiorella Sabrina Belfforte - Martha S de Sereday - Jorge Vilariño - Claudio D Gonzales - María Teresa Martínez Larrad - Mariana L Tellechea - Manuel Serrano-Ríos - Edgardo Poskus - Gustavo D Frechtel - Federico Coluccio Lescow PLOS ONE PUBLIC LIBRARY SCIENCE
Obesity and risk factors for metabolic syndrome in young people with type 1 diabetes MARIANA PRIETO - ANDREA G. KROCHIK -  EDUARDO CHALER - MERCEDES MACEIRAS1 - ANABEL VILLALBA - SILVINA VALDEZ2 - GLORIA CERRONE - MARIANA TELLECHEA - CARMEN MAZZA MEDICINA (BUENOS AIRES) MEDICINA (BUENOS AIRES)
Cardiovascular phenotype of nonalcoholic fatty liver disease: Changing the paradigm about the role of distant toxic fat accumulation on vascular disease Sookoian S - Pirola CJ HEPATOLOGY JOHN WILEY & SONS INC
Circulating microrna-122 signature in nafld and cardiovascular disease: A new endocrine system in metabolic syndrome Pirola C - Fernadez Giannotti T - Castano G - Sookoian S HEPATOLOGY JOHN WILEY & SONS INC
Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease Carlos J. Pirola - T Fernández Gianotti - Al Burgueño - Manuel Rey Funes - Cesar Fabian Loidl - Pablo Mallardi - Julio San Martino - Gustavo O Castaño - Silvia Sookoian GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY B M J PUBLISHING GROUP
DNA methylation and hepatic insulin resistance and steatosis Sookoian S - Pirola CJ CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LIPPINCOTT WILLIAMS & WILKINS
Genetic determinants of acquired cholestasis: A systems biology approach Sookoian S - Pirola CJ FRONTIERS IN BIOSCIENCE-LANDMARK FRONTIERS IN BIOSCIENCE INC
The genetic epidemiology of nonalcoholic Fatty liver disease: toward a personalized medicine Sookoian S - Pirola CJ CLINICS IN LIVER DISEASE W B SAUNDERS CO-ELSEVIER INC
Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome Silvia Sookoian - Carlos Jose PIROLA WORLD JOURNAL OF GASTROENTEROLOGY W J G PRESS
PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease Silvia Sookoian - Carlos Jose PIROLA WORLD JOURNAL OF GASTROENTEROLOGY W J G PRESS
Effect of Neonatal Clomipramine Treatment on consummatory Successive Negative Contrast Ruetti, E. - Burgueño, A. - Justel, N. - Pirola, C. - Mustaca, A. Psicologica Department of Methodology of the Behavioral Sciences of the University of Valencia (Spain)
Circulating microRNA-122 signature in nonalcoholic steatohepatitis and cardiovascular disease: a new endocrine system in metabolic syndrome Silvia Sookoian - Tomas Fernandez Gianotti - Gustavo O Castaño - Carlos Jose PIROLA HEPATOLOGY JOHN WILEY & SONS INC
Cardiovascular disease is associated with high fat diet-induced liver damage and upregulation of hepatic expression of hypoxia-inducible factor 1 alpha in a rat model Burgueño A. - Fernández Gianotti T. - Gonzales Mansilla N. - Pirola C.J. - Sookoian S. CLINICAL SCIENCE PORTLAND PRESS LTD
Obstructive Sleep Apnea Is Associated with Fatty Liver and Abnormal Liver Enzymes: a Meta-analysis Sookoian S - Pirola CJ BESITY SURGERY : THE OFFICIAL JOURNAL OF THE AMERICAN SOCIETY FOR BARIATRIC SURGERY AND OF THE OBESITY SURGERY SOCIETY OF AUSTRALIA AND NEW ZEALAND. SPRINGER
Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization Fernandez Gianotti T - Burgueño A - Gonzales Mansilla N - Pirola CJ - Sookoian S PLOS ONE PUBLIC LIBRARY SCIENCE
Systems Biology Elucidates Common Pathogenic Mechanisms between Nonalcoholic and Alcoholic-Fatty Liver Disease Sookoian S - Pirola CJ PLOS ONE PUBLIC LIBRARY SCIENCE
Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine Sookoian S - Pirola CJ CURRENT DIABETES REPORTS CURRENT MEDICINE GROUP
Fetal metabolic programming and epigenetic modifications: a systems biology approach Sookoian S - Fernadez Giannotti T - Burgueño A - Pirola CJ PEDIATRIC RESEARCH INT PEDIATRIC RESEARCH FOUNDATION, INC
Effect of Neonatal Clomipramine Treatment on consummatory Successive Negative Contrast Ruetti, E. M. - Burgueño, A. - Justel, N. R. - Pirola, C. - Mustaca, A. Psicologica Psicologica
HYROTROPIN-RELEASING HORMONE (TRH) MAY MEDIATE SYMPATHETIC ACTION AND ARTERIAL BLOOD PRESSURE INCREASE IN OFFSPRING OF MATERNAL OBESITY LANDA, MARIA SILVINA - SCHUMAN, MARIANO LUIS - Peres Diaz Ludmila - GARCIA , SILVIA INES - PIROLA, CARLOS JOSE HYPERTENSION LIPPINCOTT WILLIAMS & WILKINS
Thyrotropin-Releasing Hormone Overexpression induces structural changes of the Left Ventricle in the normal Rat heart Mariano L. Schuman - Ludmila S Peres Diaz - María S. Landa - Jorge E Toblli - Gabriel Cao - Azucena Alvarez - Samuel Finkielman - Carlos J. Pirola - Silvia I. García AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY AMER PHYSIOLOGICAL SOC
Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis Pirola CJ - Fernández Gianotti T - Castaño G - Mallardi P - San Martino J - Gonzalez Lopez Ledesma Maria Mora3 - Flichman Diego - Mirshahi Faridodin - Sanyal Arun J - Sookoian S GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY  B M J PUBLISHING GROUP
Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals SILVIA C. SOOKOIAN - Gustavo O. Castaño - Carlos J. Pirola GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY B M J PUBLISHING GROUP
NAFLD: Metabolic make-up of NASH: from fat and sugar to amino acids. Review Sookoian S;  Pirola CJ NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY NATURE PUBLISHING GROUP
PNPLA3, the history of an orphan gene of the potate tuber protein family that found an organ: the Liver Silvia Sookoian - Carlos Jose PIROLA HEPATOLOGY JOHN WILEY & SONS INC
Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells Hae-Ki Min - Sookoian S - Pirola CJ - Jianfeng Cheng - Faridoddin Mirshahi - Sanyal Aj AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY AMER PHYSIOLOGICAL SOC
Promoter DNA Methylation of Farnesoid X Receptor and Pregnane X Receptor Modulates the Intrahepatic Cholestasis of Pregnancy Phenotype Cabrerizo, R - Castaño G. - Fernandez Gianotti T - Gonzalez Lopez - Ledesma MM - Flichman, D - Carlos J. Pirola - Silvia Sookoian PLOS ONE PUBLIC LIBRARY SCIENCE
Effects of bile acid sequestration on hepatic steatosis in obese mice NANCY SOLÍS - MARGARITA PIZARRO - PABLO QUINTERO - JUAN PABLO ARAB - ARNOLDO RIQUELME - OSLANDO PADILLA - GONZALO CARRASCO - Carlos Jose PIROLA - Silvia Sookoian - MARCO ARRESE ANNALS OF HEPATOLOGY MEXICAN ASSOC HEPATOLOGY
Personalizing care for nonalcoholic fatty liver disease patients: what are the research priorities? Silvia Sookoian - Carlos Jose PIROLA PERSONALIZED MEDICINE FUTURE MEDICINE LTD
Genetic and Epigenetic Associations with NAFLD: Focus on Clinical Decision Making and Novel Concepts in Disease Pathogenesis Silvia Sookoian - Carlos J. Pirola Current Hepatology Reports Springer
Genetic variation in TM6SF2 and the risk of nonalcoholic fatty liver disease and histological disease severity. Silvia Sookoian - Gustavo O. Castaño - Romina Scian - Pablo Mallardi - Tomas Fernandez Gianotti - Adriana L. Burgueño - Julio San Martino - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
PNPLA3 I148M variant is associated with metabolic stress-response phenotype in patients with nonalcoholic fatty liver disease. Sookoian S - Castaño G - Pirola CJ HEPATOLOGY JOHN WILEY & SONS INC
The dual and opposite role of the TM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis. Pirola CJ - Sookoian S HEPATOLOGY JOHN WILEY & SONS INC
TM6SF2 as a genetic risk factor for fibrosis. SILVIA C. SOOKOIAN - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Non-alcoholic fatty liver disease and risk of cardiovascular disease Lonardo A - Sookoian S - Pirola CJ - Targher G METABOLISM-CLINICAL AND EXPERIMENTAL W B SAUNDERS CO-ELSEVIER INC
Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine. Silvia Sookoian - Carlos J. Pirola WORLD JOURNAL OF GASTROENTEROLOGY W J G PRESS
Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA-Hydroxymethylation and TET Proteins Carlos J Pirola - Romina Scian - Tomas Fernandez Gianotti - Hernan Dopazo - Cristian Rohr - Julio San Martino - Gustavo O. Castaño - Silvia Sookoian MEDICINE LIPPINCOTT WILLIAMS & WILKINS
Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension. Tellechea M - Fernadez Giannotti T - Alvariñas J - Gonzalez C - Sookoian S - Pirola CJ Scientific Reports Nature Publishing Group
Elafibranor for the treatment of NAFLD: One pill, two molecular targets and multiple effects in a complex phenotype. Sookoian S - Pirola CJ ANNALS OF HEPATOLOGY MEXICAN ASSOC HEPATOLOGY
Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH). Silvia Sookoian - Gustavo O Castaño - Romina Scian - Julio San Martino - Carlos J. Pirola Scientific Reports Nature Publishing Group
How safe is Moderate Alcohol Consumption in Overweight and Obese Individuals? Sookoian S - Pirola CJ GASTROENTEROLOGY W B SAUNDERS CO-ELSEVIER INC
Mendelian randomisation suggests no beneficial effect of moderate alcohol consumption on the severity of nonalcoholic fatty liver disease. Silvia Sookoian - Diego Flichman - Gustavo O Castaño - Carlos J. Pirola ALIMENTARY PHARMACOLOGY & THERAPEUTICS. WILEY-BLACKWELL PUBLISHING, INC
Metabolite Signatures of Metabolic Risk Factors and their Longitudinal Changes. Yin X - Subramanian S - Willinger CM - Chen G - Juhasz P - Courchesne P - Chen BH - Li X - Hwang SJ - Fox CS - O'Donnell CJ - Muntendam P - Fuster V - Bobeldijk-Pastorova I - Sookoian S - Pirola CJ - Gordon N - Adourian A - Larson MG - Levy D JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM ENDOCRINE SOC
Mitochondrial genome architecture in non-alcoholic fatty liver disease. Sookoian S - Flichman, D - Scian, R - Rohr, C - Dopazo, H - FERNANDEZ GIANOTTI, T - SAN MARTINO J - Castano G - Pirola CJ JOURNAL OF PATHOLOGY JOHN WILEY & SONS LTD
Nonalcoholic fatty liver disease and metabolicsyndrome: Shared genetic basis of pathogenesis. Silvia Sookoian - Carlos Jose PIROLA HEPATOLOGY (BALTIMORE, MD.) JOHN WILEY & SONS INC
Meta-analysis of the influence of TM6SF2 E167K variant on Plasma Concentration of Aminotransferases across different Populations and Diverse Liver Phenotypes. Silvia Sookoian - Carlos Jose PIROLA Scientific Reports Nature Publishing Group
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level. Silvia Sookoian - Gustavo O Castaño - Romina Scian - Tomas Fernández Gianotti - Hernán Dopazo - Cristian Rohr - Graciela Gaj - Julio San Martino - Ina Sevic - Diego Flichman - Carlos J Pirola AMERICAN JOURNAL OF CLINICAL NUTRITION AMER SOC CLINICAL NUTRITION
The Exact Mechanism by Which Hepatic Transmembrane 6 Superfamily Member 2 Modulates Triglyceride Metabolism Is Still Uncertain. Silvia Sookoian - Carlos Jose PIROLA GASTROENTEROLOGY W B SAUNDERS CO-ELSEVIER INC
The Modulation of Liver Methylome in Liver Diseases. Pirola CJ - Sookoian S JOURNAL OF HEPATOLOGY ELSEVIER SCIENCE BV
The impact of hypertension on leukocyte telomere length: a systematic review and meta-analysis of human studies. Mariana L Tellechea - Pirola CJ JOURNAL OF HUMAN HYPERTENSION NATURE PUBLISHING GROUP

 

Departamento Hematología Investigación

Estudio del efecto del eje CXCR4/SDF-1 en la producción plaquetaria.Estudios del receptor soluble de IL-6 en pacientes con trombocitemia esencial y otros desórdenes mieloproliferativos. Caracterización de las trombocitopenias hereditarias y estudio de los mecanismos moleculares subyacentes a la alteración en la producción y función plaquetaria en estas entidades.

Evaluar la interrelación entre los componentes del linaje megacariocítico (megacariocitos y plaquetas) y los distintos componentes que determinan la enfermedad autoinmune, como los auto-anticuerpos y la inmunidad celular. Estos estudios estuvieron enfocados a patologías en las que este linaje tiene un especial protagonismo, como son la trombocitopenia inmune y el lupus eritematoso sistémico.

Estudios de la influencia de distintos tratamientos en el tamaño plaquetario y las variables clínicas relacionadas, en neoplasias mieloproliferativas crónicas Filadelfia negativas.

Investigación del efecto de las incretinas GLP-1 y GIP sobre la función plaquetaria.

TITULO AUTORES REVISTA EDITORIAL
Production of functional platelet-like particles by the megakaryoblastic DAMI cell line provides a model for platelet biogenesis Lev PR - Goette NP - Glembotsky AC - Laguens RP - Cabeza Meckert PM - Salim JP - Heller PG - Pozner RG - Marta RF - Molinas FC PLATELETS TAYLOR & FRANCIS LTD
Production of platelet-like particles by megakaryoblastic DAMI cell line provides a model for platelet biogenesis Lev PR - Glembotsky AC - Goette NP - Heller PG - Pozner RG - Cabeza Mekert P - Laguens R - Marta RF - Molinas FC PLATELETS TAYLOR & FRANCIS LTD
International collaboration as a tool for diagnosis of patients with inherited thrombocytopenia in the setting of a developing country Glembotsky AC. - Marta RF. - Pecci A. - de Rocco D. - Gnan C. - Espasandin YR. - Goette NP. - Negro F. - Noris P.  - Savoia A. - Balduini CL. - Molinas FC. - Heller PG. JOURNAL OF THROMBOSIS AND HAEMOSTASIS WILEY-BLACKWELL PUBLISHING, INC
Correlation between platelet phenotype and NBEAL2 genotype in patients with congenital thrombocytopenia and alpha-granule deficiency Bottega Roberta - Pecci Alessandro - de Candida Erica - Pujol Moix Nuria - Heller Paula G - Noris Patrizia - De Rocco Daniela - Podda Gian Marco - Glembotsky Ana C - Cattaneo Marco - Balduini Carlo L - Savoia Anna HAEMATOLOGICA FERRATA STORTI FOUNDATION
MYH9-related disease: five novel mutations expanding the spectrum of causative mutations and confirming genotype/phenotype correlations De Rocco Daniela - Zieger Barbara - Platokouki Helen - Heller Paula G - Pastore Annalisa - Bottega Roberta - Noris Patrizia - Barozzi Serena - Glembotsky Ana C - Pergantou Helen - Balduini Carlo L - Savoia Anna - Pecci Alessandro EUROPEAN JOURNAL OF MEDICAL GENETICS ELSEVIER SCIENCE BV
Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression Bluteau D - Glembotsky Ana C - Raimbault A - Balayn N - Gilles L - Rameau P - Nurden P - Alessi MC - Debili N - Vainchenker W - Heller Paula G - Favier R - Raslova H BLOOD, THE JOURNAL OF THE AMERICAN SOCIETY OF HEMATOLOGY The American Society of Hematology
ANKRD26-related thrombocytopenia and myeloid malignancies Noris P - Favier R - Alessi MC - Geddis A - Kunishima S - Heller PG - Giordano P - Niederhoffer K - Bussel J - Podda G - Vianelli N - Kersserboom R - Pecci A -Gnan C - Marconi C - Auvrignon A - Cohen W - Yu G - Iuchi A - Miller Imahiyerobo A - Boehlen F - Ghalloussi D - De Rocco D - Magini P - Civaschi E - Biino G - Seri M - Savoia A - Balduini C BLOOD, THE JOURNAL OF THE AMERICAN SOCIETY OF HEMATOLOGY - ONLINE American Society of Hematology
Correlation between platelet phenotype and NBEAL2 genotype in patients with congenital thrombocytopenia and alpha-granule deficiency Bottega Roberta - Pecci Alessandro - de Candida Erica - Pujol Moix Nuria - Heller Paula G - Noris Patrizia - De Rocco Daniela - Podda Gian Marco - Glembotsky Ana C - Cattaneo Marco - Balduini Carlo L - Savoia Anna HAEMATOLOGICA FERRATA STORTI FOUNDATION
MYH9-related disease: a novel prognostic model to predict the clinical evolution of the disease based on genotype-phenotype correlations Pecci A - Klersy C - Gresele P - Lee K - De Rocco D - Bozzi V - Russo G - Heller PG - Loffredo F - Ballmaier M - Fabris F - Beggiato E - Kahr W - Pujol-Moix N - Platokouki H - Van Geet C - Noris P - Yerram P - Hermans C - Bernhard Gerber B - Economou M - de Groot M - Zieger B - de Candia E - Fraticelli V - Kersseboom R - Piccoli G - Zimmermann S - Fierro T - Glembotsky AC - Vianello F - Zaninetti C - Nicchia E - Güthner C - Baronci C - Seri M - Knight P - Balduini CL - Savoia A HUMAN MUTATION WILEY-LISS, DIV JOHN WILEY & SONS INC
MYH9-related disease: five novel mutations expanding the spectrum of causative mutations and confirming genotype/phenotype correlations de Rocco D. - Zieger B - Platokouki H - Heller PG. - Pastore A. - Bottega R - Noris P - Barozzi S - Glembotsky AC. - Pergantou H - Balduini CL. - Savoia A. - Pecci A. EUROPEAN JOURNAL OF MEDICAL GENETICS ELSEVIER SCIENCE BV
Estudio molecular en Neoplasias Mieloproliferativas Crónicas: mutación JAK2V617F Lev PR - Heller PG Hematología Sociedad Argentina de Hematología
Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia Noris P. - Schlegel N. - Klersy C. - Heller PG. - Civaschi E. - Pujol-Moix N. - Fabris F. - Favier R. - Gresele P. - Latger-Cannard V. - Cuker A. - Nurden P. - Greinacher A. - Cattaneo M - De Candia E. - Pecci A. - Hurtaud-Roux MF. - Glembotsky AC. - Muñiz-Diaz E. - Randi ML. - Trillot N. - Bury L. - Lecompte T. - Marconi C. - Savoia A. - Balduini CL. HAEMATOLOGICA  FERRATA STORTI FOUNDATION
Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets Glembotsky AC. - Bluteau D. - Goette NP. - Marta RF. - Marin Oyarzun CP. - Korin L. - Lev PR. - Laguens RP. - Molinas FC. - Raslova H. - Heller PG. JOURNAL OF THROMBOSIS AND HAEMOSTASIS WILEY-BLACKWELL PUBLISHING, INC
Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count Lev PR. - Grodzielski M. - Goette NP. - Glembotsky AC. - Espasandin YR. - Pierdominici MS. - Contrufo G. - Montero V. - Ferrari L. - Molinas FC. - Heller PG. - Marta RF. BRITISH JOURNAL OF HAEMATOLOGY WILEY-BLACKWELL PUBLISHING, INC
Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Noetzli L - Lo RW - Lee-Sherick AB - Callaghan M -  Noris P - Savoia A - Rajpurkar M - Jones K - Gowan K - Balduini CL - Pecci A - Gnan C - De Rocco D - Doubek M - Li L - Leung R - Landolt-Marticorena C -  Hunger S - Heller P - Gutierrez-Hartmann A -  Xiayuan L - Pluthero FG - Rowley JW - Weyrich AS - Kahr WH - Porter CC - Di Paola J  NATURE GENETICS NATURE PUBLISHING GROUP
Anagrelide platelet-lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: insight into potential mechanisms. Espasandin Y - Glembotsky AC - Grodzielski M - Lev PR - Goette NP - Molinas FC - Marta RF - Heller PG JOURNAL OF THROMBOSIS AND HAEMOSTASIS WILEY-BLACKWELL PUBLISHING, INC
Megakaryocytic emperipolesis and platelet function abnormalities in five patients with gray platelet syndrome. Larroca LM. - Heller PG - Podda GM. - Pujol-Moix N. - Glembotsky AC. - Pecci A. - Alberelli MA - Balduini CL. - Landolfi R - Cattaneo M - De Candia E. PLATELETS TAYLOR & FRANCIS LTD
Long-term follow-up of essential thrombocythemia patients treated with anagrelide: subgroup analysis according to JAK2/CALR/MPL mutational status. Mela Osorio MJ - Ferrari L1 - Goette NP - Gutierrez MI - Glembotsky AC - Maldonado AC - Lev PR - Alvarez C - Korin L - Marta RF - Molinas FC - Heller PG EUROPEAN JOURNAL OF HAEMATOLOGY WILEY-BLACKWELL PUBLISHING, INC
Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients. Di Buduo Cristian - Alberelli MA - Glembotsky AC - Podda G - Lev Pri - Cattaneo M - Landolfi R - Heller PG - Balduini A - de Candia E Scientific Reports Nature Publishing Group
Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias. Salim Juan P - Glembotsky Ana C - Lev Paola R - Marin Oyarzun Cecilia P - Goette Nora P - Molinas Felisa C - Marta Rosana F - Heller Paula G PLATELETS TAYLOR & FRANCIS LTD
Long-term follow-up of essential thrombocythemia patients treated with anagrelide: subgroup analysis according to JAK2/CALR/MPL mutational status. Mela Osorio MJ - Ferrari Luciana - Goette Nora P - Gutierrez MI - Glembotsky AC - Maldonado C - Lev Paola R - Alvarez Clarisa - Marta RF - Molinas FC - Heller PG EUROPEAN JOURNAL OF HAEMATOLOGY WILEY-BLACKWELL PUBLISHING, INC
Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms. Marin Oyarzún, Cecilia P. - Carestia, Agostina - Lev, Paola R. - Glembotsky, Ana C. - Castro Ríos, Miguel A. - Moiraghi, Beatriz - Molinas, Felisa C. - Marta, Rosana F. - Schattner, Mirta - Heller, Paula G. Scientific reports Nature Publishing Group
Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-Antibodies. Nora P. Goette - Ana C. Glembotsky - Paola R. Lev - Matías Grodzielski - Geraldine Contrufo - Marta S. Pierdominici - Yésica R. Espasandin - Dardo Riveros - Alejandro J. García - Felisa C. Molinas - Paula G. Heller - Rosana F. Marta PLOS ONE PUBLIC LIBRARY SCIENCE
Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia. Antony-Debré I - Duployez N - Bucci M - Geffroy S - Micol JB - Renneville A - Boissel N - Dhédin N - Réa D - Nelken B - Berthon C - Leblanc T - Mozziconacci MJ - Favier R - Heller PG - Abdel-Wahab O - Raslova H - Latger-Cannard V - Preudhomme C LEUKEMIA NATURE PUBLISHING GROUP

 

Departamento Hepatología Clínica y Molecular

Factores genéticos que predisponen a la enfermedad grasa del hígado. La enfermedad grasa del hígado como factor de riesgo cardiovascular. Modelos experimentales de enfermedad grasa del hígado y líneas terapeuticas.Genética de la colestasis intrahepatica del embarazo.

Arquitectura metabólica y molecular de la enfermedad grasa del hígado: Su impacto clínico.

TITULO AUTORES REVISTA EDITORIAL
Cyclooxygenase inhibition Up-regulates liver carnitine palmitoyltransferase 1A expression and improves fatty liver Rosselli MS - Burgueño AL - Pirola CJ - Sookoian S HEPATOLOGY JOHN WILEY & SONS INC
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on susceptibility and histological severity of nonalcoholic fatty liver disease Silvia Sookoian - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Methodological Concerns About a Recent Meta-Analysis of the Influence of the I148M Variant ofPatatin-Like Phospholipase Domain Containing 3 on the Susceptibility and Histological Severity of Nonalcoholic Fatty Liver Disease Silvia Sookoian - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Targeting the renin-angiotensin system: Potential beneficial effects of the angiotensin II receptor bloxkers in patients with nonalcholic steatohepatitis Silvia Sookoian - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease Sookoian S - Fernandez Gianotti T - Rosselli MS - Burgueño AL - Castaño GO - Pirola CJ ATHEROSCLEROSIS ELSEVIER IRELAND LTD
Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4 Sookoian S - Burgueño AL - Fernandez Gianotti T - Marillet G - Pirola CJ BIOLOGICAL PSYCHOLOGY ELSEVIER SCIENCE BV
Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 (STAT3) Gianotti TF - Castaño G - Gemma C - Burgueño A - Rosselli MS - Pirola CJ - Sookoian S METABOLISM-CLINICAL AND EXPERIMENTAL W B SAUNDERS CO-ELSEVIER INC
Metabolic Syndrome: From the Genetics to the Pathophysiology Silvia Sookoian - Carlos J. Pirola CURRENT HYPERTENSION REPORTS CURRENT MEDICINE GROUP
Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research Sookoian S - Fernadez Giannotti T - Burgueño A - Pirola CJ Biomolecular Concepts Walter de Gruyter GmbH & Co. KG
Cardiovascular phenotype of nonalcoholic fatty liver disease: Changing the paradigm about the role of distant toxic fat accumulation on vascular disease Sookoian S - Pirola CJ HEPATOLOGY JOHN WILEY & SONS INC
Circulating microrna-122 signature in nafld and cardiovascular disease: A new endocrine system in metabolic syndrome Pirola C - Fernadez Giannotti T - Castano G - Sookoian S HEPATOLOGY JOHN WILEY & SONS INC
Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease Carlos J. Pirola - T Fernández Gianotti - Al Burgueño - Manuel Rey Funes - Cesar Fabian Loidl - Pablo Mallardi - Julio San Martino - Gustavo O Castaño - Silvia Sookoian GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY B M J PUBLISHING GROUP
DNA methylation and hepatic insulin resistance and steatosis Sookoian S - Pirola CJ CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LIPPINCOTT WILLIAMS & WILKINS
Genetic determinants of acquired cholestasis: A systems biology approach Sookoian S - Pirola CJ FRONTIERS IN BIOSCIENCE-LANDMARK FRONTIERS IN BIOSCIENCE INC
The genetic epidemiology of nonalcoholic Fatty liver disease: toward a personalized medicine Sookoian S - Pirola CJ CLINICS IN LIVER DISEASE W B SAUNDERS CO-ELSEVIER INC
Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome Silvia Sookoian - Carlos Jose PIROLA WORLD JOURNAL OF GASTROENTEROLOGY W J G PRESS
PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease Silvia Sookoian - Carlos Jose PIROLA WORLD JOURNAL OF GASTROENTEROLOGY W J G PRESS
Circulating microRNA-122 signature in nonalcoholic steatohepatitis and cardiovascular disease: a new endocrine system in metabolic syndrome Silvia Sookoian - Tomas Fernandez Gianotti - Gustavo O Castaño - Carlos Jose PIROLA HEPATOLOGY JOHN WILEY & SONS INC
Cardiovascular disease is associated with high fat diet-induced liver damage and upregulation of hepatic expression of hypoxia-inducible factor 1 alpha in a rat model Burgueño A. - Fernández Gianotti T. - Gonzales Mansilla N. - Pirola C.J. - Sookoian S. CLINICAL SCIENCE PORTLAND PRESS LTD
Obstructive Sleep Apnea Is Associated with Fatty Liver and Abnormal Liver Enzymes: a Meta-analysis Sookoian S - Pirola CJ BESITY SURGERY : THE OFFICIAL JOURNAL OF THE AMERICAN SOCIETY FOR BARIATRIC SURGERY AND OF THE OBESITY SURGERY SOCIETY OF AUSTRALIA AND NEW ZEALAND. SPRINGER
Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization Fernandez Gianotti T - Burgueño A - Gonzales Mansilla N - Pirola CJ - Sookoian S PLOS ONE PUBLIC LIBRARY SCIENCE
Systems Biology Elucidates Common Pathogenic Mechanisms between Nonalcoholic and Alcoholic-Fatty Liver Disease Sookoian S - Pirola CJ PLOS ONE PUBLIC LIBRARY SCIENCE
Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine Sookoian S - Pirola CJ CURRENT DIABETES REPORTS CURRENT MEDICINE GROUP
Fetal metabolic programming and epigenetic modifications: a systems biology approach Sookoian S - Fernadez Giannotti T - Burgueño A - Pirola CJ PEDIATRIC RESEARCH INT PEDIATRIC RESEARCH FOUNDATION, INC
Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis Pirola CJ - Fernández Gianotti T - Castaño G - Mallardi P - San Martino J - Gonzalez Lopez Ledesma Maria Mora3 - Flichman Diego - Mirshahi Faridodin - Sanyal Arun J - Sookoian S GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY  B M J PUBLISHING GROUP
Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals SILVIA C. SOOKOIAN - Gustavo O. Castaño - Carlos J. Pirola GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY B M J PUBLISHING GROUP
NAFLD: Metabolic make-up of NASH: from fat and sugar to amino acids. Review Sookoian S;  Pirola CJ NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY NATURE PUBLISHING GROUP
PNPLA3, the history of an orphan gene of the potate tuber protein family that found an organ: the Liver Silvia Sookoian - Carlos Jose PIROLA HEPATOLOGY JOHN WILEY & SONS INC
Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells Hae-Ki Min - Sookoian S - Pirola CJ - Jianfeng Cheng - Faridoddin Mirshahi - Sanyal Aj AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY AMER PHYSIOLOGICAL SOC
Promoter DNA Methylation of Farnesoid X Receptor and Pregnane X Receptor Modulates the Intrahepatic Cholestasis of Pregnancy Phenotype Cabrerizo, R - Castaño G. - Fernandez Gianotti T - Gonzalez Lopez - Ledesma MM - Flichman, D - Carlos J. Pirola - Silvia Sookoian PLOS ONE PUBLIC LIBRARY SCIENCE
Effects of bile acid sequestration on hepatic steatosis in obese mice NANCY SOLÍS - MARGARITA PIZARRO - PABLO QUINTERO - JUAN PABLO ARAB - ARNOLDO RIQUELME - OSLANDO PADILLA - GONZALO CARRASCO - Carlos Jose PIROLA - Silvia Sookoian - MARCO ARRESE ANNALS OF HEPATOLOGY MEXICAN ASSOC HEPATOLOGY
Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA-Hydroxymethylation and TET Proteins Carlos J Pirola - Romina Scian - Tomas Fernandez Gianotti - Hernan Dopazo - Cristian Rohr - Julio San Martino - Gustavo O. Castaño - Silvia Sookoian MEDICINE LIPPINCOTT WILLIAMS & WILKINS
Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension. Tellechea M - Fernadez Giannotti T - Alvariñas J - Gonzalez C - Sookoian S - Pirola CJ Scientific Reports Nature Publishing Group
Genetic variation in TM6SF2 and the risk of nonalcoholic fatty liver disease and histological disease severity. Silvia Sookoian - Gustavo O. Castaño - Romina Scian - Pablo Mallardi - Tomas Fernandez Gianotti - Adriana L. Burgueño - Julio San Martino - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
PNPLA3 I148M variant is associated with metabolic stress-response phenotype in patients with nonalcoholic fatty liver disease. Sookoian S - Castaño G - Pirola CJ HEPATOLOGY JOHN WILEY & SONS INC
The dual and opposite role of the TM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis. Pirola CJ - Sookoian S HEPATOLOGY JOHN WILEY & SONS INC
TM6SF2 as a genetic risk factor for fibrosis. SILVIA C. SOOKOIAN - Carlos J. Pirola HEPATOLOGY JOHN WILEY & SONS INC
Non-alcoholic fatty liver disease and risk of cardiovascular disease Lonardo A - Sookoian S - Pirola CJ - Targher G METABOLISM-CLINICAL AND EXPERIMENTAL W B SAUNDERS CO-ELSEVIER INC
Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine. Silvia Sookoian - Carlos J. Pirola WORLD JOURNAL OF GASTROENTEROLOGY W J G PRESS
Nonalcoholic fatty liver disease Brunt E - Wong V - Nobili V - Day C - Sookoian S - Maher M - Bugianesi E - Sirlin C - Neuschwander-Tetri - Rinella M Nat. Rev. Dis. Primers Macmillan Publishers
Elafibranor for the treatment of NAFLD: One pill, two molecular targets and multiple effects in a complex phenotype. Sookoian S - Pirola CJ ANNALS OF HEPATOLOGY MEXICAN ASSOC HEPATOLOGY
Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH). Silvia Sookoian - Gustavo O Castaño - Romina Scian - Julio San Martino - Carlos J. Pirola Scientific Reports Nature Publishing Group
How safe is Moderate Alcohol Consumption in Overweight and Obese Individuals? Sookoian S - Pirola CJ GASTROENTEROLOGY W B SAUNDERS CO-ELSEVIER INC
Mendelian randomisation suggests no beneficial effect of moderate alcohol consumption on the severity of nonalcoholic fatty liver disease. Silvia Sookoian - Diego Flichman - Gustavo O Castaño - Carlos J. Pirola ALIMENTARY PHARMACOLOGY & THERAPEUTICS. WILEY-BLACKWELL PUBLISHING, INC
Metabolite Signatures of Metabolic Risk Factors and their Longitudinal Changes. Yin X - Subramanian S - Willinger CM - Chen G - Juhasz P - Courchesne P - Chen BH - Li X - Hwang SJ - Fox CS - O'Donnell CJ - Muntendam P - Fuster V - Bobeldijk-Pastorova I - Sookoian S - Pirola CJ - Gordon N - Adourian A - Larson MG - Levy D JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM ENDOCRINE SOC
Mitochondrial genome architecture in non-alcoholic fatty liver disease. Sookoian S - Flichman, D - Scian, R - Rohr, C - Dopazo, H - FERNANDEZ GIANOTTI, T - SAN MARTINO J - Castano G - Pirola CJ JOURNAL OF PATHOLOGY JOHN WILEY & SONS LTD
Nonalcoholic fatty liver disease and metabolicsyndrome: Shared genetic basis of pathogenesis. Silvia Sookoian - Carlos Jose PIROLA HEPATOLOGY (BALTIMORE, MD.) JOHN WILEY & SONS INC
Meta-analysis of the influence of TM6SF2 E167K variant on Plasma Concentration of Aminotransferases across different Populations and Diverse Liver Phenotypes. Silvia Sookoian - Carlos Jose PIROLA Scientific Reports Nature Publishing Group
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level. Silvia Sookoian - Gustavo O Castaño - Romina Scian - Tomas Fernández Gianotti - Hernán Dopazo - Cristian Rohr - Graciela Gaj - Julio San Martino - Ina Sevic - Diego Flichman - Carlos J Pirola AMERICAN JOURNAL OF CLINICAL NUTRITION AMER SOC CLINICAL NUTRITION
The Exact Mechanism by Which Hepatic Transmembrane 6 Superfamily Member 2 Modulates Triglyceride Metabolism Is Still Uncertain. Silvia Sookoian - Carlos Jose PIROLA GASTROENTEROLOGY W B SAUNDERS CO-ELSEVIER INC
The Modulation of Liver Methylome in Liver Diseases. Pirola CJ - Sookoian S JOURNAL OF HEPATOLOGY ELSEVIER SCIENCE BV

 

Departamento Nefrología Experimental

Síntesis y liberación de Dopamina renal.Estudio de la progresión de la poliquistosis renal.Sistema kallikreína kinina y hormonas sexuales, mecanismos de regulación. Genotipificación para apolipoproteína E (APO E) para el estudio como factor de riesgo de la Enfermedad de Alzehimer

TITULO AUTORES REVISTA EDITORIAL
Rol del sistema kalikreína kinina y su interrelación con sistemas vasoactivos durante la preñez Elisabet Oddo - Elvira E Arrizurieta MEDICINA (BUENOS AIRES) MEDICINA (BUENOS AIRES)
Trasplante renal con dador vivo relacionado en Poliquistosis Renal Autonómica Dominante (ADPKD): Un Enfoque Bioético. Adriana R. Fraga Revista Argentina de Transplantes Sociedad Argentina de Trasplante
Evaluación del filtrado glomerular en nefropatía por diabetes, en actualización de los aspectos metabólicos y las complicciones de los pacientes con diabetes y enfermedad renal. diagnóstico y tratamiento  ADRIANA R FRAGA REVISTA DE LA SOCIEDAD ARGENTINA DE DIABETES Sociedad Argentina de Diabetes
PATTERNS OF RENAL DOPAMINE RELEASE TO REGULATE DIURESIS AND NATRIURESIS DURING VOLUME EXPANSION.ROLE OF RENAL MONOAMINE-OXIDASE Verónica De Luca sarobe - Luis Di Ciano - Andrea M Carranza - Gloria Levin - Elvira E Arrizurieta - Fernando R Ibarra MEDICINA (BUENOS AIRES)  MEDICINA (BUENOS AIRES)
DETECCION DE ENFERMEDAD RENAL CRÓNICA. DOCUMENTO MULTIDISCIPLINARIO Alerto Alles - Adriana Fraga - Roberto García - Alejandra Gómez - Gustavo Greloni - Felipe Inserra - Daniel Mazziotta - María Lía Torres - Alberto Torres Nefrologia Argentina Publicaciones Latinoamericanas S.R.L.

 

Departamento Neurofisiología

Mecanismos de facilitación presináptica de la liberación espontánea y evocada de acetilcolina inducida por agonistas de los receptores de adenosina A2A en terminales nerviosas motoras. Efecto modulador de la inosina (clásicamente considerado metabolito de la adenosina) sobre la liberación espontánea y evocada de acetilcolina en sinapsis neuromuscular de mamífero. Identificación de los receptores a los cuales se une. Identificación de los receptores P2Y de ATP que producen inhibición presin}áptica de la secreción del neurotransmisor en sinapsis motoras de mamífero. Efectos directos e indirectos de las hormonas sexuales sobre las diferencias en actividad eléctrica cardiaca observadas entre machos y hembras.Análisis temporal y geométrico durante la dispersión de la repolarización ventricular en un modelo de corazón de mamífero. Diferencias en actividad eléctrica cardiaca observadas entre machos y hembras. Efectos hormonales y no hormonales. Incrementos de la dispersión de la repolarización ventricular y su riesgo asociado a arritmias ventriculares severas y/o muerte súbita.

Efecto de las purinas endógenas sobre la secreción del neurotransmisor durante distintos patrones de estimulación nerviosa en sinapsis neuromuscular de ratones CF1.

TITULO AUTORES REVISTA EDITORIAL
Excitatory effect of the A2A adenosine receptor agonist CGS-21680 on spontaneous and K+ evoked ACh release at the mouse neuromuscular junction Alejandra G Palma - Salomon MUCHNIK - Adriana Losavio NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD
Influencia de la madurez sexual y la castración sobre la actividad eléctrica cardíaca en conejos machos y hembras. Eizikovits, Gabriela Y - Casal, Carolina - Arini, Pedro D - Bertrán, Guillermo C MEDICINA (BUENOS AIRES) MEDICINA (BUENOS AIRES)
Excitatory effect of the A2A adenosine receptor agonist CGS-21680 on spontaneous and K+ evoked ACh release at the mouse neuromuscular junction Alejandra G Palma - Salomon MUCHNIK - Adriana Losavio NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD
Inosine induces presynaptic inhibition of acetylcholine release by activation of A3 adenosine receptors at the mouse neuromuscular junction Alejandro Cinalli - Juan Guarracino - Verónica Fernandez - Adriana Losavio BRITISH JOURNAL OF PHARMACOLOGY WILEY-BLACKWELL PUBLISHING, INC
P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. Juan F. Guarracino - Alejandro Cinalli - Verónica Fernandez - Liliana Roquel - Adriana Losavio NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD

 

Departamento Parasitología Molecular

Estudio de las vías de síntesis rápida de ATP en Trypanosoma cruzi, el agente etiológico del Mal de Chagas. En particular aquellas que involucran fosfotransferasas como la arginina quinasa y las adenilato quinasas, bajo la hipótesis de la existencia de una red de transferencia de fosfatos de alta energía en el parásito. Caracterización bioquímica y molecular de los mecanismos de regulación de estas rutas metabólicas, incluyendo la utilización de parásitos modificados genéticamente. Estudio del transporte y metabolismo de aminoácidos en tripanosomátidos, identificación y caracterización de posibles transportadores utilizando técnicas bioinformáticas y expresión en sistemas heterólogos.

Identificación de blancos terapéuticos de T. cruzi y desarrollo de drogas para su aplicación en la enfermedad de Chagas.

TITULO AUTORES REVISTA EDITORIAL
TcNDPK2, a Trypanosoma cruzi microtubule-associated nucleoside diphosphate kinase Miranda MR - Camara MM - Bouvier LA - Pereira CA MOLECULAR AND BIOCHEMICAL PARASITOLOGY ELSEVIER SCIENCE BV
Arginine kinase is present in Phytomonas, a trypanosomatid parasite of plants CANEPA, Gaspar - CARRILLO, Carolina - MIRANDA, Mariana - SAYE, Melisa - PEREIRA, CA COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY ELSEVIER SCIENCE INC
New enzymes as potential therapeutic targets for trypanosomiases and leishmaniasis PEREIRA, CA - SILBER, Ariel - Gonzalez Rey, Elena Enzyme Research Hindawi Publishing Corporation
Singular features of trypanosomatids’ phosphotransferases involved in cell energy management PEREIRA, CA - BOUVIER, Leon - CAMARA, Maria de los Milagros - MIRANDA, Mariana Enzyme Research Hindawi Publishing Corporation
Unique features of trypanosomatid phosphotransferases involved in nucleotide homeostasis Pereira CA - Bouvier LA - Camara MM - Miranda MR Enzyme Research Hindawi Publishing Corporation
Lysine transporters in human trypanosomatid pathogens INBAR, Ehud - CANEPA, Gaspar - CARRILLO, Carolina - GLASSER, Fabian - SUTTER GROTEMEYER, Marianne - RENTSCH, Doris - ZILBERSTEIN, Dan - PEREIRA, CA AMINO ACIDS SPRINGER
Cationic amino acid uptake constitutes a metabolic regulation mechanism and occurs in the flagellar pocket of Trypanosoma cruzi MIRANDA, Mariana - SAYE, Melisa - BOUVIER, Leon - CAMARA, Maria de los Milagros - MONTSERRAT, Javier - PEREIRA, CA PLOS ONE PUBLIC LIBRARY SCIENCE
On the evolution of hexose transporters in kinetoplastid protozoans PEREIRA, CA - SILBER, Ariel PLOS ONE PUBLIC LIBRARY SCIENCE
Identification of a Trypanosoma cruzi glycosomal adenylate kinase containing an unusual peroxisomal targeting signal CAMARA, Maria de los Milagros - BOUVIER, Leon  -MIRANDA, Mariana - PEREIRA, CA EXPERIMENTAL PARASITOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
In silico analysis of Trypanosomatids’ helicases GARGANTINI, PABLO - LUJAN, HUGO DANIEL - PEREIRA, CALUDIO A FEMS MICROBIOLOGY LETTERS WILEY-BLACKWELL PUBLISHING, INC
Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines Digirolamo Fabio - Sabatini Diego - Fasan Raul - Echogoyen Maia - Vela Mauro - PEREIRA, CA - Maure Pablo VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY ELSEVIER SCIENCE BV
La vía de transducción de señales TOR de mamíferos está presente en Trypanosoma cruzi. Reconstrucción in silico y posibles funciones Digirolamo F - Miranda M - Bouvier LA - Camara MM - Canepa GE - Pereira CA MEDICINA (BUENOS AIRES) MEDICINA (BUENOS AIRES)
Molecular and functional characterization of a Trypanosoma cruzi nuclear adenylate kinase isoform CAMARA, Maria de los Milagros - BOUVIER, Leon - CANEPA, Gaspar - MIRANDA, Mariana - PEREIRA, CA PLOS NEGLECTED TROPICAL DISEASES PUBLIC LIBRARY SCIENCE
Plasmid vectors and molecular building blocks for the development of genetic manipulation tools for Trypanosoma cruzi Bouvier LA - Camara MM - Canepa GE - Miranda MR - Pereira CA PLOS ONE PUBLIC LIBRARY SCIENCE
Laboratory techniques to obtain different forms of Trypanosoma cruzi: applications to wild-type and genetically modified parasites Camara MM - Bouvier LA - Miranda MR - Reigada C - Pereira CA FOLIA PARASITOLOGICA FOLIA PARASITOLOGICA
Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but? how to deal with them? PEREIRA, CA - SAYE, Melisa - WRENGER, Carsten - MIRANDA, Mariana CURRENT MEDICINAL CHEMISTRY BENTHAM SCIENCE PUBL LTD
MRSA Infections: From Classical Treatment to Suicide Drugs Drebes, Julia - Künz, Madeleine - PEREIRA, CA - Betzel, Christian - WRENGER, Carsten CURRENT MEDICINAL CHEMISTRY BENTHAM SCIENCE PUBL LTD
A comparative study on phosphotransferase activity of acid phosphatases from Raoultella planticola and Enterobacter aerogenes on nucleosides, sugars, and related compounds MEDICI, Rosario - GARAYCOCHEA, J - VALINO, A - PEREIRA, CA - LEWKOWICS, E - IRIBARREN, Adolfo APPLIED MICROBIOLOGY AND BIOTECHNOLOGY SPRINGER
Proline modulates the Trypanosoma cruzi resistance to reactive oxygen species and drugs through a novel D, L-proline transporter SAYE M - MIRANDA MR - DI GIROLAMO F - CAMARA MM - PEREIRA CA PLOS ONE PUBLIC LIBRARY SCIENCE
Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi María V. Díaz - Mariana R. Miranda - Carolina Campos Estrada - Chantal Reigada - Juan D. Maya - Claudio A. Pereira - Rodrigo López Muñoz ACTA TROPICA ELSEVIER SCIENCE BV
Cytosolic Trypanosoma cruzi nucleoside diphosphate kinase generates large granules that depend on its quaternary structure PEREIRA CA - REIGADA C - SAYE M - DI GIROLAMO F - MIRANDA MR EXPERIMENTAL PARASITOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
A Preventive Cytokine Treatment of the Viral Infectious Bursal Disease (IBD) of Chickens MATTIELLO R - D´AMBROSIO E - WILDA M - MARTÍNEZ SAYÉ M - MIRANDA MR - MAURE P - PEREIRA CA - DI GIROLAMO F JOURNAL OF POULTRY SCIENCE JAPAN POULTRY SCIENCE ASSOC
The flagellar adenylate kinases of Trypanosoma cruzi CAMARA, Maria de los Milagros - BOUVIER, Leon1 -  MIRANDA, Mariana - PEREIRA, CA FEMS MICROBIOLOGY LETTERS WILEY-BLACKWELL PUBLISHING, INC
Phytomonas: a non-pathogenic trypanosomatid model for functional expression of proteins Miranda MR - Saye M - Reigada C - Carrillo C - Pereira CA PROTEIN EXPRESSION AND PURIFICATION ACADEMIC PRESS INC ELSEVIER SCIENCE
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target. Seguel V - Castro L - Reigada C - Cortes L - Díaz MV - Miranda MR - Pereira CA - Lapier M - Campos-Estrada C - Morello A - Kemmerling U - Maya JD - López-Muñoz R EXPERIMENTAL PARASITOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
Resveratrol inhibits Trypanosoma cruzi arginine kinase and exerts a trypanocidal activity. Edward A. Valera Vera - Melisa Sayé - Chantal Reigada - Flávia S. Damasceno - Ariel M. Silber - Mariana R. Miranda - Claudio A. Pereira INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ELSEVIER SCIENCE BV
Trypanosoma cruzi contains two galactokinases; molecular and biochemical characterization. Ángel E. Lobo-Rojas - Eglys B. González-Marcano - Edward A. Valera Vera - Héctor R. Acosta PARASITOLOGY INTERNATIONAL ELSEVIER IRELAND LTD
Trypanosoma cruzi Polyamine Transporter: Its Role on Parasite Growth and Survival Under Stress Conditions. Chantal Reigada - Edward A. Valera Vera - Darío Balcazar - Laura Fraccaroli - Carolina Carrillo - Mariana R. Miranda - Claudio A. Pereira JOURNAL OF MEMBRANE BIOLOGY SPRINGER
Trypanosoma cruzi Proline Transport Presents a Cell Density-dependent Regulation Melisa Martinez Sayé - Mariana R. Miranda - Chantal Reigada - Claudio A. Pereira JOURNAL OF EUKARYOTIC MICROBIOLOGY WILEY-BLACKWELL PUBLISHING, INC

 

Departamento Psicologia Experimental y Aplicada

Bases psicofisiologicas y ontogenia de la frustración. Frustración y euforia: Generalización de la Ley de Weber al contraste entre incentivos.

TITULO AUTORES REVISTA EDITORIAL
Effects of pretraining treatment with testosterone on successive and anticipatory negative contrast Justel, N. - Ruetti, E. - Mustaca, A. E. - Papini, M. Physiology & Behavior PERGAMON-ELSEVIER SCIENCE LTD
Long-lasting effects of perinatal asphyxia on exploration, memory and incentive downshift Galeano, Pablo - Blanco Calvo, Eduardo - Madureira de Oliveira, Diêgo - Cuenya, Lucas - Kamenetzky, Giselle Vanesa - Mustaca, Alba Elizabeth - Barreto, George Emilio - Giraldez-Alvarez, Lisandro Diego  - Milei, José - Capani, Francisco INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD
Correlación entre miedo incondicionado y la primera reacción a la disminución y extinción de un reforzador apetitivo Kamenetzky, G - Cuenya, L - Mustaca, A Acta de Investigación Psicológica División de Investigación y Posgrado de la Facultad de Psicología de la UNAM
Neonatal treatment with clomipramine and depression: review of physiological and behavioral findings Justel, N. - Bentosela, M, - Mustaca, A. - Ruetti, E. Interdisciplinaria Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines (CIIPCA)
Efectos del aislamiento en la adultez sobre el dolor y la frustración Cuenya, L. - Fosacheca, S. - Mustaca, A. - Kamenetzky, G Psicologica Department of Methodology of the Behavioral Sciences of the University of Valencia (Spain)
Efecto del diacepam sobre la Extinción consumatoria Justel, N - Mustaca, A - Bentosela, M - Ruetti, E Revista Argentina de Ciencias del Comportamiento Universidad Nacional de Córdoba
Estudio sobre Maltrato Infantil en Niños y Adolescentes de la Provincia de Buenos Aires Norma I. Sánchez - Lucas Cuenya Revista Argentina de Ciencias del Comportamiento Universidad Nacional de Córdoba
Evaluación objetiva de los tratamientos psicológicos: modelos basados en la ciencia Mustaca, A Revista colombiana de Psicología Universidad de Colombia
Effects of pretraining treatment with testosterone on successive and anticipatory negative contrast Justel, N - Ruetti, E - Mustaca, A - Papini, M PHYSIOLOGY AND BEHAVIOR PERGAMON-ELSEVIER SCIENCE LTD
The effect of partial reinforcement on instrumental successive negative contrast in inbred Roman High- (RHA-I) and Low- (RLA-I) Avoidance rats Cuenya, L - Sabariego, M - Donaire, R - Fernández Teruel, A - Tobeña, A - Gómez, M - Mustaca, A PHYSIOLOGY AND BEHAVIOR PERGAMON-ELSEVIER SCIENCE LTD
Effects of Isolation in Adulthood on Frustration and Anxiety Cuenya, L. - Fosacheca, S. - Mustaca, A. - Kamenetzky, G. BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV
Memoria del sabor Justel, N - Ruetti, E Revista Argentina de Ciencias del Comportamiento Universidad Nacional de Córdoba
Discriminación de sabores en procedimientos de cambios sorpresivos del reforzador durante la temprana ontogenia de la rata Suárez, Andrea - Mustaca, Alba - Pautassi Ricardo - Kamenetzky, Giselle SUMA PSICOLOGICA Fundación Universitaria Konrad Lorenz
Effect of Neonatal Clomipramine Treatment on consummatory Successive Negative Contrast Ruetti, E. - Burgueño, A. - Justel, N. - Pirola, C. - Mustaca, A. Psicologica Department of Methodology of the Behavioral Sciences of the University of Valencia (Spain)
Consummatory suppression due to incentive downshift is not a consequence of enhanced search behavior Lopez Seal, María Florencia - Cuenya, Lucas - Suarez, Andrea - Mustaca, Alba BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV
La exposición a la música favorece la consolidación de los recuerdos Justel, N. - Rubinstein, W. Boletín de Psicología Promolibro
Respecto de la controversia sobre la clasificación de los trastornos psicológicos Mustaca, A. Psciencia Asociación para el avance de la Ciencia psicológica
Evaluation of the effects of spatial optimism and temporal pessimism in assessments of environmental conditions in Argentina Jakovcevic A. - Ferreiro, J. - Páramo, P. - Mustaca, A Psyecology Fundacion Infancia y Aprendizaje
EN BUSCA DE LA MEMORIA: EL NACIMIENTO DE UNA NUEVA CIENCIA DE LA MENTE Ruetti, E. Psyencia Asociacion para el Avance de la Ciencia Psicologica
“Siento un dolor en el alma”: ¿metáfora o realidad? Mustaca, A. Revista Argentina de Ciencias del Comportamiento Facultad de Psicología. Universidad Nacional de Cordoba
Diferencias individuales en las respuestas de frustración Cuenya, L. - Fosacheca, S. - Mustaca, A Revista Argentina de Ciencias del Comportamiento Facultad de Psicología. Universidad Nacional de Cordoba
Modulación de la memoria emocional: Una revisión de los principales factores que afectan los recuerdos Justel Nadia - Psyrdellis Mariana - Ruetti Eliana SUMA PSICOLOGICA Fundación Universitaria Konrad Lorenz
Effect of Neonatal Clomipramine Treatment on consummatory Successive Negative Contrast Ruetti, E. M. - Burgueño, A. - Justel, N. R. - Pirola, C. - Mustaca, A. Psicologica Psicologica
Propranolol reverses open field effects on frustration Justel N - Psyrdellis M - Pautassi RM - Mustaca A NEUROBIOLOGY OF LEARNING AND MEMORY ACADEMIC PRESS INC ELSEVIER SCIENCE
Postweaning isolation affects responses to incentive contrast in adulthood Lucas Cuenya - Alba E. Mustaca - Giselle Kamenetzky DEVELOPMENTAL PSYCHOBIOLOGY JOHN WILEY & SONS INC
Corticosterone and propranolol´s role on taste recognition memory Ruetti, E. - Justel, N. - Mustaca, A. - Boccia, M. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR PERGAMON-ELSEVIER SCIENCE LTD
Mediational Role of Hormones in Incentive Contrast Justel, N. - Pautasi. R. - Mustaca JOURNAL OF COMPARATIVE PSYCHOLOGY AMER PSYCHOLOGICAL ASSOC
Incentive relativity in middle aged rats Justel, N. - Mustaca, A. - Boccia, M. - Ruetti, E NEUROSCIENCE LETTERS ELSEVIER IRELAND LTD
Proactive interference of open field on consummatory successive negative contrast Justel, N. - Pautassi, R. - Mustaca, A. LEARNING & BEHAVIOR PSYCHONOMIC SOC INC
Evaluación y modulación de la memoria emocional: Un estudio preliminar Justel, N. - Psyrdellis, M. - Ruetti, E. Anuario de Investigaciones Facultad de Psicología, UBA
Memoria emocional en adultos mayores: Evaluación del recuerdo de estímulos negativos Justel, N. - Ruetti, E. Cuadernos de Neuropsicología. Panamerican Journal of Neuropsychology CNPS
Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados Justel, N. - Psyrdellis, M. Interdisciplinaria Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines (CIIPCA)
Early experience and incentive relativity in adulthood Cuenya, L. - Kamenetzky, G. - Mustaca, A. International Journal of Comparative Psychology International Society of Comparative Psychology
Mediational role of hormones in incentive contrast Justel N - Pautassi RM - Psyrdellis M - Mustaca A International Journal of Comparative Psychology University of California - eScholarship
Aprendizajes Sensoriales Tempranos y su Relación con las Conductas de Apego Ifrán, María Celeste - Suárez, Andrea - Kamenetzky, Giselle Revista Argentina de Ciencias del Comportamiento Universidad Nacional de Córdoba
Postweaning isolation affects responses to incentive contrast in adulthood Cuenya, L.. - Mustaca, A - Kamenetzky, G. DEVELOPMENTAL PSYCHOBIOLOGY JOHN WILEY & SONS INC
Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente Cuenya, L. - Serafini, M. - Mustaca, A. E. -  Kamenetzky, G. Revista Argentina de Ciencias del Comportamiento Universidad Nacional de Córdoba
La improvisación musical Una mirada compartida entre la musicoterapia y las neurociencias Diaz Abrahan, V. - Justel, N. Psicogente Universidad Simon Bolivar
Open field exposure facilitates recovery from an aversive emotional event: Involvement of adrenergic and cholinergic transmitter systems. Psyrdellis M - Pautassi R - Justel N NEUROSCIENCE LETTERS ELSEVIER IRELAND LTD
Cholinergic transmission underlies modulation of frustration by open field exposure. Psyrdellis Mariana - Pautassi Ricardo - Mustaca Alba - Justel Nadia PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR PERGAMON-ELSEVIER SCIENCE LTD
Complex effects of reward upshift on consummatory behavior. Annicchiarico, I - Glueck, A - Cuenya, L - Kawasaki, K - Conrad, S. E. - Papini, M. R. BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV
Efecto de la música sobre la memoria emocional verbal. Justel Nadia - Diaz Abrahan Veronika - Castro Candela - Rubinstein W. Anuario de Investigaciones Facultad de Psicologia
Exploration of a novel object in late adolescence predicts novelty-seeking behavior in adulthood: Associations among behavioral responses in four novelty-seeking tests. Cuenya, L. - Sabariego, M. - Donaire, R. - Callejas Aguilera, J. E. - Torres, C. - Fernández-Teruel, A. BEHAVIOURAL PROCESSES ELSEVIER SCIENCE BV
Open field exposure facilitates consummatory extinction. Justel N. - Psyderllis M. - Pautassi R.M. NEUROREPORT LIPPINCOTT WILLIAMS & WILKINS
Rock influences spatial memory in adult rats, while classical music do not. Diaz Abrahan, V - Cetratelli, C. - Justel, N THE BRITISH JOURNAL OF CLINICAL PSYCHOLOGY / THE BRITISH PSYCHOLOGICAL SOCIETY Journal Psychological
Uso del propranolol como modulador de la memoria y el aprendizaje en modelos animales. Mariana Psyrdellis - Nadia Justel Avances en Psicología Latinoamericana Universidad del Rosario

 

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